Diphenhydramine HCL 25mg
Generic For: Benadryl
Medication as Low as $20.00
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- Step 1Choose TreatmentSelect your treatment and quantity.
- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
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Diphenhydramine is an allergy medicine. It relieves sneezing, itching, hives, and allergic reactions, and can cause drowsiness.
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100-day supply · $0.20/tablet
Refill up to 3 times without a new visit — fast processing.
Price: $20.00
HSA/FSA Eligible+ $30 provider review & $10 shipping only charged if approved
Order Now- Medication$20
- Provider review$30
- Shipping$10
- Total$60
Only charged if approved
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Only charged if a provider approves your prescription
Refill up to 3 times without a new visit — fast processing.
Estimated delivery: Thu–Fri, Oct 22–23 · discreet packaging
- Only charged if a provider approves your prescription
- Estimated delivery: Thu–Fri, Oct 22–23
See price breakdown
Medication$20.00
Provider review$30.00
Shipping$10.00
Estimated total$60.00
Estimated delivery: Thu–Fri, Oct 22–23
How It Works
- Step 1Choose TreatmentSelect your treatment and quantity.
- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
Licensed U.S. PharmacyVerify license →LegitScript CertifiedVerify certification →
Discreet ShippingPlain, unmarked packaging
Secure CheckoutEncrypted & protected.
Diphenhydramine HCL 25mg
A first-generation antihistamine for allergic reactions, hives, and itching
What Diphenhydramine HCL 25mg Treats
Brand nameBenadryl
Drug classFirst-generation antihistamine
TreatsAllergic reactions, hives, itching, seasonal allergies
FormTablet
Typical dosingTake 1 tablet by mouth every 4 to 6 hours as needed for allergic symptoms.
Prescription requiredNo — available over the counter
What is Diphenhydramine HCL 25mg?
Diphenhydramine HCl 25mg (brand name Benadryl) is a first-generation antihistamine available in tablet form. It works by blocking histamine, a natural substance the body releases during allergic reactions. Diphenhydramine is used to relieve allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and itching, and it is also used for occasional sleeplessness and motion sickness. Because it causes drowsiness, it is often taken at night or when alertness is not required.
What it treats
- Allergy symptoms (sneezing, runny nose, itchy/watery eyes)
- Hay fever (allergic rhinitis)
- Common cold symptoms (runny nose, sneezing)
- Itching and hives (urticaria)
- Occasional sleeplessness (insomnia)
- Motion sickness (prevention and treatment)
- Allergic skin reactions
How to Take Diphenhydramine HCL 25mg
- Allergies/cold: 25–50 mg by mouth every 4–6 hours as needed; max 300 mg/24 hours.
- Sleep aid: 50 mg by mouth once at bedtime as needed.
- Motion sickness: 25–50 mg by mouth 30 minutes before travel, then before meals and at bedtime as needed.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Diphenhydramine HCL 25mg Side Effects
Common side effects
- Drowsiness
- Dizziness
- Dry mouth, nose, or throat
- Constipation
- Blurred vision
- Thickened mucus
- Difficulty urinating
- Nausea
Serious side effects: get medical help right away
Stop taking this medication and seek medical attention right away if you experience:
- Fast, pounding, or irregular heartbeat
- Difficulty or painful urination
- Confusion, agitation, or hallucinations
- Seizures
- Severe allergic reaction (rash, swelling of face/throat, trouble breathing)
Warnings & Interactions
- Causes marked drowsiness; do not drive or operate machinery until you know how it affects you
- Avoid alcohol and other sedating medicines (sleep aids, tranquilizers) while taking this drug
- Use caution with glaucoma, enlarged prostate, difficulty urinating, or breathing problems such as asthma or emphysema
- Do not use with any other product containing diphenhydramine, including topical products
- Older adults may be more sensitive to side effects such as confusion, dizziness, and falls
- Ask a doctor or pharmacist before use if pregnant or breastfeeding
- Do not take with MAO inhibitors or within 14 days of stopping an MAOI
Tell your prescriber about all medications, supplements, and health conditions before starting diphenhydramine hcl 25mg.
Medical Review & Sources
Diphenhydramine HCL 25mg FAQ
What is diphenhydramine 25mg used for?
Diphenhydramine 25mg is an antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and hives. It is also used for occasional sleeplessness and to prevent or treat motion sickness.
Is diphenhydramine the same as Benadryl?
Yes, Benadryl is the brand name for diphenhydramine. Both contain the same active ingredient and work the same way when taken at equivalent doses.
Do I need a prescription for Diphenhydramine HCL 25mg?
For Diphenhydramine HCL 25mg orders through our website, the prescription can be provided through our telehealth consultation if a licensed provider approves the treatment. Complete our online health questions for the provider to review. If approved, the prescription is sent directly to All Family Pharmacy for pharmacist review, dispensing, and shipping directly to your front door. You do not need to get a prescription from your primary care provider first.
How long does diphenhydramine make you sleepy?
Drowsiness from diphenhydramine typically lasts about 4 to 6 hours, though some people feel groggy longer, especially older adults. Avoid driving or activities requiring alertness until you know how it affects you.
Can I take diphenhydramine every night for sleep?
Diphenhydramine is intended for occasional sleeplessness, not long-term nightly use. If your sleep problems persist for more than two weeks, talk to your doctor, as this may signal an underlying condition.
How does ordering and shipping work?
Your Diphenhydramine HCL 25mg prescription can be provided through our telehealth consultation. Select your medication and complete the online health questions. A licensed provider reviews your health information and, if clinically appropriate, issues the prescription and sends it directly to All Family Pharmacy. Our licensed pharmacists review it before dispensing and shipping your medication directly to your front door. You do not need to obtain a prescription from your primary care provider first.
Can I take diphenhydramine with alcohol?
No, alcohol should be avoided while taking diphenhydramine. Combining them can significantly increase drowsiness, dizziness, and impairment, raising the risk of accidents.
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