Estradiol 0.1% Gel 0.5 mg Packets
Generic For: Divigel
Medication as Low as $105.00
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Estradiol is a form of the hormone estrogen. This gel is rubbed on the thigh once a day to help with hot flashes and night sweats.
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30-day supply · $3.50/packet
Refill up to 3 times without a new visit — fast processing.
Price: $105.00
HSA/FSA Eligible+ $30 provider review & $10 shipping only charged if approved
Order Now- Medication$105
- Provider review$30
- Shipping$10
- Total$145
Only charged if approved
✓ In your cart
Only charged if a provider approves your prescription
Refill up to 3 times without a new visit — fast processing.
Estimated delivery: Thu–Fri, Oct 22–23 · discreet packaging
- Only charged if a provider approves your prescription
- Estimated delivery: Thu–Fri, Oct 22–23
See price breakdown
Medication$105.00
Provider review$30.00
Shipping$10.00
Estimated total$145.00
Estimated delivery: Thu–Fri, Oct 22–23
How It Works
- Step 1Choose TreatmentSelect your treatment and quantity.
- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
Licensed U.S. PharmacyVerify license →LegitScript CertifiedVerify certification →
Discreet ShippingPlain, unmarked packaging
Secure CheckoutEncrypted & protected.
Estradiol 0.1% Gel 0.5 mg Packets
An estrogen gel applied to the thigh once daily for menopause hot flashes and night sweats
What Estradiol 0.1% Gel 0.5 mg Packets Treats
Brand nameDivigel
Drug classEstrogen (hormone therapy)
TreatsModerate to severe hot flashes and night sweats due to menopause
FormGel
Typical dosingApply the contents of 1 packet (0.5 mg) to the right or left upper thigh once daily, alternating sides each day.
Prescription requiredYes — prescription only
What is Estradiol 0.1% Gel 0.5 mg Packets?
Estradiol 0.1% Gel is a clear, fast-drying gel that contains estradiol, the main estrogen made by the ovaries. Each single-dose foil packet holds 0.5 grams of gel, which delivers 0.5 mg of estradiol through the skin. It is the generic version of Divigel and is FDA-approved to treat moderate to severe hot flashes and night sweats (vasomotor symptoms) due to menopause. It comes in five strengths, from 0.25 mg to 1.25 mg, so your provider can use the lowest dose that controls your symptoms.
What it treats
- Moderate to severe hot flashes due to menopause
- Night sweats due to menopause
How to Use Estradiol 0.1% Gel 0.5 mg Packets
- Start with 0.25 mg (one 0.25 g packet) once daily; your provider may adjust up to a maximum of 1.25 mg daily.
- Apply the full packet to the right or left upper thigh, alternating sides each day, over an area about 5 by 7 inches.
- Do not apply to the face, breasts, irritated skin, or in or around the vagina.
- Let the gel dry before dressing, do not wash the area for 1 hour, and wash your hands after applying.
- Use the lowest effective dose and reassess periodically.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Estradiol 0.1% Gel 0.5 mg Packets Side Effects
Common side effects
- Spotting or irregular vaginal bleeding
- Breast tenderness
- Vaginal yeast infection
- Cold symptoms (stuffy nose, sore throat)
- Upper respiratory infection
- Skin irritation at the application site
Serious side effects: get medical help right away
Stop using this medication and seek medical attention right away if you experience:
- Signs of a blood clot (leg pain or swelling, chest pain, shortness of breath)
- Stroke symptoms (sudden weakness, vision changes, slurred speech, severe headache)
- Heart attack symptoms (chest pressure, pain spreading to arm or jaw)
- New breast lumps
- Unusual or heavy vaginal bleeding
- Yellowing of the skin or eyes
Warnings & Interactions
- Boxed warning: estrogen alone increases the risk of endometrial cancer in women with a uterus; a progestogen is usually added
- Do not use with undiagnosed abnormal genital bleeding
- Do not use with current or past breast cancer or estrogen-dependent cancer
- Do not use with active or past blood clots, stroke, or heart attack, or with liver disease
- Alcohol-based gel is flammable; avoid fire, flame, or smoking until it dries
- Estradiol can transfer to others through skin contact; cover the area once dry and wash hands after use
- Sunscreen and other lotions on the same area may change how much estradiol is absorbed
Tell your prescriber about all medications, supplements, and health conditions before starting estradiol 0.1% gel 0.5 mg packets.
Medical Review & Sources
Estradiol 0.1% Gel 0.5 mg Packets FAQ
What is estradiol gel used for?
Estradiol 0.1% gel treats moderate to severe hot flashes and night sweats caused by menopause. It delivers estrogen through the skin once a day.
Is this the same as Divigel?
Yes. It is the generic version of Divigel, with the same active ingredient (estradiol 0.1%) in the same single-dose packet strengths.
Do I need a prescription for estradiol gel?
Yes. You complete a short telehealth visit, and a licensed provider decides whether estradiol gel is right for you.
How does ordering and shipping work?
After you complete a health questionnaire, a licensed provider reviews your information. If a prescription is issued, your medication ships from a licensed U.S. pharmacy directly to your door.
How do I apply estradiol gel?
Once a day, squeeze out the whole packet and spread it over about a 5 by 7 inch area of your upper thigh, switching thighs each day. Let it dry before dressing, wait 1 hour before washing the area, and wash your hands afterward.
Do I need to take progesterone with estradiol gel?
If you still have your uterus, your provider will usually add a progestogen to lower the risk of endometrial cancer. Women who have had a hysterectomy usually do not need one.
Can estradiol gel rub off on others?
Yes. Estradiol can transfer through skin contact. Let the gel dry, cover the area with clothing, and wash your hands so children and partners do not come into contact with it.
What are the most common side effects?
The most common side effects are spotting, breast tenderness, vaginal yeast infections, and cold symptoms. Contact your provider right away for leg swelling, chest pain, sudden vision changes, or unusual vaginal bleeding.
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