Estradiol 10mcg Vaginal Inserts
Generic For: Vagifem
Medication as Low as $60.00
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- Step 1Choose TreatmentSelect your treatment and quantity.
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- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
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Estradiol vaginal inserts deliver a low dose of estrogen directly to the vagina. They help relieve vaginal dryness, itching, burning, and painful intercourse caused by menopause.
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28-day supply · $7.50/tablet
Refill up to 3 times without a new visit — fast processing.
Price: $60.00
HSA/FSA Eligible+ $30 provider review & $10 shipping only charged if approved
Order Now- Medication$60
- Provider review$30
- Shipping$10
- Total$100
Only charged if approved
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Only charged if a provider approves your prescription
Refill up to 3 times without a new visit — fast processing.
Estimated delivery: Thu–Fri, Oct 22–23 · discreet packaging
- Only charged if a provider approves your prescription
- Estimated delivery: Thu–Fri, Oct 22–23
See price breakdown
Medication$60.00
Provider review$30.00
Shipping$10.00
Estimated total$100.00
Estimated delivery: Thu–Fri, Oct 22–23
How It Works
- Step 1Choose TreatmentSelect your treatment and quantity.
- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
Licensed U.S. PharmacyVerify license →LegitScript CertifiedVerify certification →
Discreet ShippingPlain, unmarked packaging
Secure CheckoutEncrypted & protected.
Estradiol 10mcg Vaginal Inserts
Low-dose estradiol vaginal inserts used to treat vaginal dryness, itching, and burning from menopause.
What Estradiol 10mcg Vaginal Inserts Treats
Brand nameVagifem
Drug classEstrogen hormone
TreatsAtrophic vaginitis (vaginal dryness, itching, burning) due to menopause
FormTablet
Typical dosingInsert 1 tablet vaginally once daily for 2 weeks, then 1 tablet twice weekly.
Prescription requiredYes — prescription only
What is Estradiol 10mcg Vaginal Inserts?
Estradiol 10 mcg vaginal inserts are small tablets placed in the vagina with a disposable applicator. They release a low dose of estradiol, a form of estrogen, right where it is needed. After menopause, lower estrogen levels can thin and dry the vaginal tissue, causing dryness, itching, burning, and pain during sex. The inserts help restore that tissue. They are the generic version of Vagifem and require a prescription.
What it treats
Atrophic vaginitis due to menopause (vaginal dryness, itching, burning, and painful intercourse)
How to Take Estradiol 10mcg Vaginal Inserts
- Starting dose: 1 insert (10 mcg) vaginally once daily for 2 weeks.
- Maintenance dose: 1 insert vaginally twice weekly (for example, Monday and Thursday).
- Insert gently into the vagina as far as comfortable using the applicator, preferably at the same time of day.
- Use the lowest effective dose for the shortest duration; reassess periodically.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Estradiol 10mcg Vaginal Inserts Side Effects
Common side effects
- Headache
- Vaginal spotting or discharge
- Vaginal itching or irritation
- Breast tenderness
- Nausea
- Back or abdominal pain
Serious side effects: get medical help right away
Stop taking this medication and seek medical attention right away if you experience:
- Signs of blood clot (leg pain/swelling, chest pain, sudden shortness of breath)
- Stroke symptoms (sudden weakness, slurred speech, vision changes)
- New breast lumps
- Unusual or heavy vaginal bleeding
- Severe headache or migraine
- Yellowing of skin or eyes (possible liver problems)
Warnings & Interactions
- Boxed warning: increased risk of endometrial cancer, stroke, blood clots, and probable dementia (in women 65+); estrogen-alone therapy should not be used to prevent cardiovascular disease
- Do not use with undiagnosed abnormal genital bleeding
- Do not use with known or suspected breast cancer or estrogen-dependent cancer
- Do not use with active or prior blood clots (DVT, PE), stroke, or heart attack
- Do not use during pregnancy or with liver disease
- Women with a uterus generally need a progestin added to reduce endometrial cancer risk
- CYP3A4 inducers (e.g., St. John's wort, rifampin) may reduce effectiveness; inhibitors may increase side effects
Tell your prescriber about all medications, supplements, and health conditions before starting estradiol 10mcg vaginal inserts.
Medical Review & Sources
Estradiol 10mcg Vaginal Inserts FAQ
What are estradiol vaginal inserts used for?
They treat vaginal dryness, itching, burning, and painful intercourse caused by thinning vaginal tissue after menopause.
Do I need a prescription for estradiol vaginal inserts?
Yes. Estradiol is a prescription-only medication in the U.S. A licensed healthcare provider must review whether it is appropriate for you before it can be dispensed.
Is this the same as Vagifem?
Yes. These are the generic version of Vagifem, with the same active ingredient at the same 10 mcg strength. Your pharmacist can confirm which version you will receive.
How do I use estradiol vaginal inserts?
Insert 1 tablet vaginally once daily for the first 2 weeks, then 1 tablet twice weekly. Use the applicator to place it gently as far as comfortable.
How long does a pack last?
On the twice-weekly maintenance dose, 8 inserts last about 4 weeks, 16 last about 8 weeks, and 24 last about 12 weeks. The first 2 weeks of daily use take 14 inserts.
How does ordering and shipping work?
After you place your order and complete a provider review, a licensed pharmacist checks it. Once approved, your medication ships from a licensed U.S. pharmacy to your address.
What are the most important risks to know about?
Estrogen products carry a boxed warning for increased risks of endometrial cancer, blood clots, stroke, and probable dementia in older women. Seek medical care right away for leg swelling, chest pain, sudden shortness of breath, or unusual vaginal bleeding.
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