Fluorouracil 5% Cream
Generic For: Efudex
Medication as Low as $45.00
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Fluorouracil 5% cream, sold under the brand name Efudex, is a prescription topical chemotherapy medication. It works by destroying abnormal, fast-growing skin cells while largely sparing healthy skin. It is most commonly used to treat actinic keratosis (precancerous sun-damaged skin patches) and certain superficial basal cell carcinomas.
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30-day supply · $1.13/gram
Refill up to 3 times without a new visit — fast processing.
Price: $45.00
HSA/FSA Eligible+ $30 provider review & $10 shipping only charged if approved
Order Now- Medication$45
- Provider review$30
- Shipping$10
- Total$85
Only charged if approved
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Only charged if a provider approves your prescription
Refill up to 3 times without a new visit — fast processing.
Estimated delivery: Thu–Fri, Oct 22–23 · discreet packaging
- Only charged if a provider approves your prescription
- Estimated delivery: Thu–Fri, Oct 22–23
See price breakdown
Medication$45.00
Provider review$30.00
Shipping$10.00
Estimated total$85.00
Estimated delivery: Thu–Fri, Oct 22–23
How It Works
- Step 1Choose TreatmentSelect your treatment and quantity.
- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
Licensed U.S. PharmacyVerify license →LegitScript CertifiedVerify certification →
Discreet ShippingPlain, unmarked packaging
Secure CheckoutEncrypted & protected.
Fluorouracil 5% Cream
Topical chemotherapy cream for actinic keratosis and superficial basal cell carcinoma
What Fluorouracil 5% Cream Treats
Brand nameEfudex
Drug classTopical antineoplastic (antimetabolite)
TreatsActinic keratosis, superficial basal cell carcinoma
FormCream
Typical dosingApply a thin layer to the affected areas twice daily for 3 to 6 weeks, or as directed (up to 10 to 12 weeks). Wash hands right after applying
Prescription requiredYes — prescription only
What is Fluorouracil 5% Cream?
Fluorouracil 5% cream (Efudex) is a prescription topical medication classified as an antineoplastic antimetabolite. It interferes with the growth of abnormal skin cells by blocking DNA production, causing damaged cells to die and slough off. It is FDA-approved to treat multiple actinic (solar) keratoses, which are rough, precancerous patches caused by sun damage. The 5% strength is also approved for superficial basal cell carcinoma when conventional treatments such as surgery are impractical.
What it treats
- Actinic keratosis (multiple actinic or solar keratoses)
- Superficial basal cell carcinoma (when conventional methods are impractical)
- Precancerous sun-damaged skin lesions on the face and scalp
- Sun-damaged lesions on other body areas as directed by a prescriber
How to Use Fluorouracil 5% Cream
- Actinic keratosis: Apply a thin layer to lesions twice daily for 2–4 weeks.
- Superficial basal cell carcinoma: Apply twice daily for 3–6 weeks; up to 10–12 weeks may be needed.
- Apply with a nonmetal applicator or gloved fingertip; wash hands after use.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Fluorouracil 5% Cream Side Effects
Common side effects
- Burning or stinging at application site
- Redness and inflammation
- Dryness, scaling, or crusting
- Itching
- Pain or soreness
- Skin erosion where applied
- Temporary skin discoloration
Serious side effects: get medical help right away
Stop using this medication and seek medical attention right away if you experience:
- Severe pain, blistering, or ulceration of treated skin
- Signs of allergic reaction (rash, swelling, trouble breathing)
- Severe stomach pain, bloody diarrhea, or vomiting (possible DPD deficiency)
- Fever, chills, or signs of infection at the treatment site
- Mouth sores or unusual bleeding or bruising
Warnings & Interactions
- Contraindicated during pregnancy; may cause fetal harm
- Contraindicated in patients with dihydropyrimidine dehydrogenase (DPD) deficiency
- For external use only; avoid eyes, nostrils, mouth, and mucous membranes
- Increased sensitivity to sunlight; avoid prolonged UV exposure during treatment
- Do not use occlusive dressings unless directed; may increase skin inflammation
- Do not breastfeed while using this medication
- Treated areas may look worse before healing begins
Tell your prescriber about all medications, supplements, and health conditions before starting fluorouracil 5% cream.
Medical Review & Sources
Fluorouracil 5% Cream FAQ
Do I need a prescription for fluorouracil 5% cream?
Yes. Fluorouracil cream is a prescription-only medication in the United States. A licensed healthcare provider must evaluate your skin condition and approve the prescription before the pharmacy can dispense it.
What is fluorouracil 5% cream used for?
Fluorouracil 5% cream is FDA-approved to treat multiple actinic (solar) keratoses, which are precancerous patches caused by sun damage. The 5% strength is also approved for superficial basal cell carcinoma when standard treatments like surgery are not practical.
How long does it take for fluorouracil cream to work?
For actinic keratosis, treatment usually lasts 2 to 4 weeks, and healing may continue for 1 to 2 months after stopping. Skin often becomes red, irritated, and crusted during treatment, which is an expected part of how the medication works.
Is fluorouracil cream the same as Efudex?
Yes. Efudex is the brand name for fluorouracil 5% cream. Generic fluorouracil 5% cream contains the same active ingredient and is held to the same FDA standards.
Can I be in the sun while using fluorouracil cream?
Fluorouracil increases your skin's sensitivity to sunlight, so you should minimize sun exposure and avoid tanning beds during treatment. Ask your prescriber about sun protection for treated areas, since some sunscreens may irritate the skin while it is healing.
How does ordering and shipping work?
After your prescription is verified or a licensed provider reviews your information and approves treatment, our U.S.-licensed pharmacy fills and ships your order in discreet packaging. A pharmacist is available to answer questions about your medication.
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