Naltrexone 1% Cream
Compounded ProductMedication as Low as $50.00
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- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
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Naltrexone 1% Cream is a compounded topical form of naltrexone, an opioid antagonist best known in oral form for treating alcohol use disorder and opioid dependence. Applied to the skin as low dose naltrexone, the cream is prescribed off-label to help manage chronic itching (pruritus) and certain inflammatory skin conditions. It works locally by blocking opioid receptors in the skin that are involved in itch and inflammation signaling.
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30-day supply · $1.00/gram
Refill up to 3 times without a new visit — fast processing.
Price: $50.00
HSA/FSA Eligible+ $30 provider review & $10 shipping only charged if approved
Order Now- Medication$50
- Provider review$30
- Shipping$10
- Total$90
Only charged if approved
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Only charged if a provider approves your prescription
Refill up to 3 times without a new visit — fast processing.
Estimated delivery: Thu–Fri, Oct 22–23 · discreet packaging
- Only charged if a provider approves your prescription
- Estimated delivery: Thu–Fri, Oct 22–23
See price breakdown
Medication$50.00
Provider review$30.00
Shipping$10.00
Estimated total$90.00
Estimated delivery: Thu–Fri, Oct 22–23
How It Works
- Step 1Choose TreatmentSelect your treatment and quantity.
- Step 2Complete Health QuestionsAnswer a brief medical intake.
- Step 3Provider ReviewA licensed provider reviews your information.
- Step 4Pharmacy ShipsIf approved, your prescription is filled and shipped.
Licensed U.S. PharmacyVerify license →LegitScript CertifiedVerify certification →
Discreet ShippingPlain, unmarked packaging
Secure CheckoutEncrypted & protected.
Naltrexone 1% Cream
Compounded topical opioid antagonist cream used for chronic itching, inflammatory skin conditions, and localized pain
What Naltrexone 1% Cream Treats
Drug classOpioid antagonist (topical)
TreatsChronic itching (pruritus), inflammatory skin conditions, localized skin discomfort
FormCream
Typical dosingApply a thin layer to affected area(s) twice daily.
Prescription requiredYes — prescription only
What is Naltrexone 1% Cream?
Naltrexone is an opioid receptor antagonist, a medication that blocks the effects of opioids at receptor sites in the body. While oral naltrexone is FDA-approved for alcohol use disorder and opioid dependence, Naltrexone 1% Cream is a compounded topical formulation prescribed off-label. When applied to the skin, low dose naltrexone may reduce itch and inflammation by acting on opioid receptors in skin tissue. Because it is applied locally, systemic absorption is generally lower than with oral naltrexone, though side effects are still possible.
What it treats
- Chronic itching (pruritus)
- Lichen simplex chronicus
- Prurigo nodularis
- Hailey-Hailey disease (off-label)
- Itch associated with atopic dermatitis (off-label)
- Localized inflammatory skin conditions (off-label)
How to Use Naltrexone 1% Cream
- Apply a thin layer to the affected area topically 1 to 2 times daily, or as directed by the prescriber.
- Wash hands after application unless treating the hands.
- Compounded product; dosing is individualized — follow the prescription label.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Naltrexone 1% Cream Side Effects
Common side effects
- Skin irritation at application site
- Redness or rash
- Dryness or peeling
- Itching or burning at application site
- Headache
- Nausea
- Sleep disturbances (with systemic absorption)
Serious side effects: get medical help right away
Stop using this medication and seek medical attention right away if you experience:
- Allergic reaction (hives, swelling, difficulty breathing)
- Severe or worsening skin reaction
- Signs of opioid withdrawal in opioid-dependent patients
- Severe dizziness or confusion
- Signs of liver problems (dark urine, yellowing of skin or eyes)
Warnings & Interactions
- Do not use if currently taking opioid medications — naltrexone can trigger sudden opioid withdrawal
- Do not use with current physiologic opioid dependence
- Naltrexone may block the effect of opioid pain medications, including those needed in an emergency
- Avoid alcohol while using naltrexone unless your prescriber advises otherwise
- Use caution with liver disease; report signs of liver injury promptly
- For external use only — avoid eyes, mouth, and broken skin
- Tell your provider if you are pregnant or breastfeeding before use
Tell your prescriber about all medications, supplements, and health conditions before starting naltrexone 1% cream.
Medical Review & Sources
Naltrexone 1% Cream FAQ
What is naltrexone?
Naltrexone is an opioid antagonist, a medication that blocks opioid receptors in the body. In oral form it is FDA-approved for alcohol use disorder and opioid dependence, while Naltrexone 1% Cream is a compounded topical form prescribed off-label, most often for chronic itching and certain skin conditions.
What is naltrexone used for?
Oral naltrexone is used to treat alcohol use disorder and to help prevent relapse in opioid dependence. The 1% cream is a compounded topical formulation used off-label for chronic pruritus (itching) and inflammatory skin conditions. Your prescriber will determine whether it is appropriate for your situation.
How does naltrexone work?
Naltrexone blocks opioid receptors. Applied topically as a cream, it acts on opioid receptors in the skin that play a role in itch and inflammation signaling. Because it is applied locally, less of the drug typically reaches the bloodstream than with oral naltrexone.
What to avoid when taking low dose naltrexone?
Avoid all opioid medications, including some prescription pain relievers and certain cough or anti-diarrheal products, as naltrexone can block their effect or trigger withdrawal. Most prescribers also recommend limiting or avoiding alcohol. Tell your provider about all medications and supplements you take.
What are low dose naltrexone side effects?
Common side effects of the cream include skin irritation, redness, dryness, or itching at the application site. If enough is absorbed, some people report headache, nausea, or vivid dreams and sleep changes. Contact your provider if you experience severe or persistent side effects.
Do I need a prescription for Naltrexone 1% Cream?
Yes. Naltrexone is a prescription-only medication in the United States, including compounded topical forms. A licensed provider must evaluate you and issue a valid prescription before the pharmacy can dispense it.
How does ordering and shipping work?
After you complete your order and a licensed provider reviews your health information, an approved prescription is sent to the pharmacy. The medication is then prepared and shipped to your address from a licensed U.S. pharmacy in discreet packaging.
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